Stereoselective synthesis of the (R)- and (S)-1-(2-amino-3-nitrophenoxy)-3-(tert-butylamino)-2-propanol from the enantiomeric glycidyl tosylates
โ Scribed by Akli Hammadi; Christian Crouzel
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 181 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0957-4166
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๐ SIMILAR VOLUMES
The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p
## Abstract Enantiomers of metoprolol containing six deuterium atoms in the isopropyl methyl groups were prepared in two steps from the sodium salt of 4โ(2โmethoxyethyl)phenol (3) and the commercially available (2__R__)โ and (2__S__)โglycidyl 3โnitrobenzenesulfonates [(2__R__)โ2 and (2__S__)โ2]. Th
The title synthesis could be accomplished by featuring the [2+21-cycloaddition reaction of a chiral imine with benzyloxyketene, alcoholysis of the formed 2-azetidinone derivative, and reductive removal of the mandelate-derived benzylic oxygen by way of a 2-oxazolidone derivative. Optically active 3