The Synthesis and Insecticidal Activity of a Series of 2-Aryl-1,2,3-triazoles
โ Scribed by Boddy, Ian K.; Briggs, Geoff G.; Harrison, Richard P.; Jones, Tim H.; O'Mahony, Mary J.; Marlow, Ian D.; Roberts, Brian G.; John Willis, R.; Bardsley, Richard; Reid, Jim
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 538 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1526-498X
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โฆ Synopsis
Two synthetic routes to 2-aryl-l,2,3-triazoles are outlined. These have been used to synthesise a wide range of compounds of this structural type. Their insecticidal activities were evaluated against a number of veterinary and public health pests. The activity of these compounds is especially good against the housefly (Musca dornestica). Structure-activity relationships are discussed particularly in relation to the physical properties of the compounds.
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Two series of novel triazole containing 14-member macrolides having either a cladinose or a 3-pyridyl acetate group at the 3-position of the macrolide ring were synthesized. The in vitro antibacterial activities against S. aureus, S. pneumoniae, S. pyogenes and E. faecalis were determined. Macrolide
Condensation of 4-methylsulfonylaniline with aryl aldehyde in ethanol-tetrahydrofuran afforded the imino compound 3. 1,3-Cycloaddtion of diazomethane with compound 3 followed by oxidazation of the triazoline 4 with potassium permanganate gave 1-(4-methylsulfonylphenyl)-5-aryl-1,2,3-triazoles 5. Simi
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