✦ LIBER ✦

Synthesis and antibacterial activity of novel 4-aryl-[1,2,3]-triazole containing macrolides

✍ Scribed by David Pereira; Prabhavathi Fernandes

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 874 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.10.091

No coin nor oath required. For personal study only.

✦ Synopsis

Two series of novel triazole containing 14-member macrolides having either a cladinose or a 3-pyridyl acetate group at the 3-position of the macrolide ring were synthesized. The in vitro antibacterial activities against S. aureus, S. pneumoniae, S. pyogenes and E. faecalis were determined. Macrolide 7a and the fluoroketolide 1 (CEM-101) were evaluated in vivo in murine systemic infection models. All of the macrolide analogs were less active in vitro and in vivo than the fluoroketolide 1 (CEM-101).

📜 SIMILAR VOLUMES

Synthesis and Antibacterial Activity of

Synthesis and Antibacterial Activity of Novel Bifunctional Macrolides.

✍ Irini Akritopoulou-Zanze; Kathleen M. Phelan; Thomas G. Marron; Hong Yong; Zhenk 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

Synthesis, Antibacterial and Surface Act

Synthesis, Antibacterial and Surface Activity of 1,2,4-Triazole Derivatives.

✍ Refat El-Sayed 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Synthesis, Antibacterial and Antifungal

Synthesis, Antibacterial and Antifungal Activity of Some Novel 3,5-Disubstituted-1H-1,2,4-triazoles

✍ Shweta Sharma; Saloni Gangal; Abdul Rauf; Maryam Zahin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 383 KB 👁 2 views

Synthesis and Antibacterial Activities o

Synthesis and Antibacterial Activities of 4-Amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl) -5-mercapto-1, 2,4-triazoles/2- Amino-5-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles and Their Derivatives

✍ Yan Zhang; Xiao-Wen Sun; Xin-Ping Hui; Zi-Yi Zhang; Qin Wang; Qi Zhang 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB

ChemInform Abstract: Synthesis, Antifung

ChemInform Abstract: Synthesis, Antifungal Activity and Antibacterial Evaluation of Some 3-Piperazinylmethyl-5-aryl-1H-1,2,4-triazoles.

✍ S. S. PAPAKONSTANTINOU-GAROUFALIAS; O. G. TODOULOU; E. C. FILIPPATOS; A. E. PAPA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Synthesis and antibacterial activity of

Synthesis and antibacterial activity of some novel N2-hydroxymethyl and N2-aminomethyl derivatives of 4-aryl-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

✍ Tomasz Plech; Monika Wujec; Barbara Kaproń; Urszula Kosikowska; Anna Malm 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

In this investigation, several novel N2hydroxymethyl and N2-aminomethyl derivatives of 5-(3-chlorophenyl)-4-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3thione were prepared. All synthesized compounds were screened fo