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Synthesis and antibacterial activity of some novel N2-hydroxymethyl and N2-aminomethyl derivatives of 4-aryl-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

✍ Scribed by Tomasz Plech; Monika Wujec; Barbara Kaproń; Urszula Kosikowska; Anna Malm

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 248 KB
Volume: 22
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20737

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✦ Synopsis

In this investigation, several novel N2hydroxymethyl and N2-aminomethyl derivatives of 5-(3-chlorophenyl)-4-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3thione were prepared. All synthesized compounds were screened for their antibacterial activity against six Gram-positive and four Gram-negative bacterial strains.

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