Synthesis of the enantiomer of the antidepressant tranylcypromine
✍ Scribed by René Csuk; Magda J. Schabel; Yvonne von Scholz
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 511 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A Catalytic Enantioselective Synthesis of Antidepressant Tranylcypromine. -Via an asymmetric cyclopropanation of styrene (I) as the key step, the title compound (-)-(V) is synthesized. -(SHU, FU-CHANG;
Sodium borohydride reduction of 3-chloro-1-(2-thienyl)-1-propanone gave the corresponding racemic alcohol which was kinetically resolved with lipase B from Candida antarctica as catalyst to yield the chiral building blocks (S)-3-chloro-1-(2thienyl)-1-propanol and the corresponding (R)-butanoate. The
The synthesis of the enantiomers of bupropion, (ruc)-2-tevt-butylamino-3'chloropropiophenone 1 (Wellbutrin@) is described. The enantiomers were compared with the racemate in both the tetrabenazine-induced sedation model and the inhibition of uptake of biogenic amine assay. No significant differences