Chemo-enzymatic synthesis of the antidepressant duloxetine and its enantiomer

✍ Scribed by Huiling Liu; Bård Helge Hoff; Thorleif Anthonsen

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 83 KB
• Volume: 12
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/(sici)1520-636x(2000)12:1<26::aid-chir5>3.0.co;2-z

✦ Synopsis

Sodium borohydride reduction of 3-chloro-1-(2-thienyl)-1-propanone gave the corresponding racemic alcohol which was kinetically resolved with lipase B from Candida antarctica as catalyst to yield the chiral building blocks (S)-3-chloro-1-(2thienyl)-1-propanol and the corresponding (R)-butanoate. The enantiopure chiral building blocks were converted into Duloxetine and its enantiomer.