Sodium borohydride reduction of 3-chloro-1-(2-thienyl)-1-propanone gave the corresponding racemic alcohol which was kinetically resolved with lipase B from Candida antarctica as catalyst to yield the chiral building blocks (S)-3-chloro-1-(2thienyl)-1-propanol and the corresponding (R)-butanoate. The
✦ LIBER ✦
Chemo-Enzymatic Method for the Synthesis of Statine, Phenylstatine and Analogues
✍ Scribed by Spiros Kambourakis; J. David Rozzell
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 104 KB
- Volume
- 345
- Category
- Article
- ISSN
- 1615-4150
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## Abstract The complete manuscript of this communication appears in: __Angew. Chem. Suppl. 1982__, 1440. DOI:10.1002/anie.198214400