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Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2)

โœ Scribed by Sai Kiran Sharma; Baker Jawabrah Al-Hourani; Melinda Wuest; Jonathan Y. Mane; Jack Tuszynski; Vickie Baracos; Mavanur Suresh; Frank Wuest


Book ID
113495724
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
390 KB
Volume
20
Category
Article
ISSN
0968-0896

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4,5-Diaryloxazole inhibitors of cyclooxy
โœ John J. Talley; Stephen R. Bertenshaw; David L. Brown; Jeffery S. Carter; Mathew ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 96 KB ๐Ÿ‘ 1 views

A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2