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Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitors

✍ Scribed by Chu, Xue-Ping; Zhou, Qing-Fa; Zhao, Shen; Ge, Fei-Fei; Fu, Mian; Chen, Jia-Peng; Lu, Tao


Book ID
120059889
Publisher
Chinese Electronic Periodical Services
Year
2013
Tongue
English
Weight
281 KB
Volume
24
Category
Article
ISSN
1001-8417

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A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.