Selective COX-2 inhibitors. Part 1: Synthesis and biological evaluation of phenylazobenzenesulfonamides
β Scribed by Wei-Jern Tsai; Young-Ji Shiao; Shwu-Jiuan Lin; Wen-Fei Chiou; Lie-Chwen Lin; Tsang-Hsiung Yang; Che-Ming Teng; Tain-Shung Wu; Li-Ming Yang
- Book ID
- 108074070
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 120 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0960-894X
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A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
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