Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle
✍ Scribed by Jacques Yves Gauthier; Yves Leblanc; W. Cameron Black; Chi-Chung Chan; Wanda A. Cromlish; Robert Gordon; Brian P. Kennedey; Cheuk K. Lau; Serge Léger; Zhaoyin Wang; Diane Ethier; Jocelyne Guay; Joseph Mancini; Denis Riendeau; Philip Tagari; Philip Vickers; Elizabeth Wong; Lijing Xu; Peptiboon Prasit
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 269 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v