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ChemInform Abstract: Synthesis and Biological Evaluation of 5,6-Diarylimidazo(2.1-b) thiazole as Selective COX-2 Inhibitors.

✍ Scribed by M. THERIEN; C. BRIDEAU; C. C. CHAN; W. A. CROMLISH; J. Y. GAUTHIER; R. GORDON; G. GREIG; S. KARGMAN; C. K. LAU; Y. LEBLANC; C.-S. LI; G. P. O'NEILL; D. RIENDEAU; P. ROY; Z. WANG; L. XU; P. PRASIT

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable via the β€œReferences” option.

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ChemInform Abstract: A New Series of Selective COX-2 Inhibitors: 5,6-Diarylthiazolo(3,2-b)( 1,2,4)triazoles.
✍ P. ROY; Y. LEBLANC; R. G. BALL; C. BRIDEAU; C. C. CHAN; N. CHAURET; W. CROMLISH; πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB

Diarylthiazolo(3,2b) ( 1,2,4)triazoles. -Sixteen title compounds such as (I) are prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. Most of the analogues in the series are very potent against the COX-2 enzyme. All of the compounds exhibit good selectivity in