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Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression

✍ Scribed by Yuji Kuge; Yumiko Katada; Sayaka Shimonaka; Takashi Temma; Hiroyuki Kimura; Yasushi Kiyono; Chiaki Yokota; Kazuo Minematsu; Koh-ichi Seki; Nagara Tamaki; Kazue Ohkura; Hideo Saji

Book ID
116798943
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
240 KB
Volume
33
Category
Article
ISSN
0969-8051

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## Abstract The expression of thymidine phosphorylase (TP) is strongly associated with angiogenesis in tumors and activation of antitumor agents. We designed a novel 5‐^125^I‐labeled 6‐(2‐iminoimidazolidinyl)methyluracil hydrochloride ([^125^I]5I6IMU‐HCl) to develop an effective radiotracer for __i