𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and evaluation of daunorubicin-paclitaxel dimers

✍ Scribed by Ari K Kar; Patrick D Braun; Thomas J Wandless

Book ID
104364949
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
320 KB
Volume
10
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.

✦ Synopsis

Bifunctional, heterodimeric compounds were synthesized to test their ability to create polyvalent arrays between DNA and microtubules in cells. Each dimer was examined for the capacity to bind to microtubules and for cytotoxicity against MES-SA and MES-SA/Dx5 cell lines.

πŸ“œ SIMILAR VOLUMES

Synthesis of paclitaxel (docetaxel) / 2-
Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers
✍ Giovanni Appendino; Emanuela Belloro; Sven Jakupovic; Bruno Danieli; Jasmin Jaku πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 772 KB

Starting from taxenes available in multigram amounts from widespread ornamental yews (10deacetylbaccatin Ill (4) and 2'-deacetoxyaustrospicatine ( )), two dimeric taxoids (3a, 3b) with potential dual target specificity ([3-tubulin end P-gp) were synthesised. Both compounds lacked significant cytotox

Synthesis and evaluation of C-seco pacli
Synthesis and evaluation of C-seco paclitaxel analogues
✍ Giovanni Appendino; Bruno Danieli; Jasmin Jakupovic; Emanuela Belloro; Giovanni πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 267 KB

Starting from 7,9-diTes-10-dehydro C-secobaccatin Ili (4a), C-seco analogues of paclitaxel retaining biological activity were synthesised.