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Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

โœ Scribed by Giovanni Appendino; Emanuela Belloro; Sven Jakupovic; Bruno Danieli; Jasmin Jakupovic; Ezio Bombardelli

Book ID
104209393
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
772 KB
Volume
55
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Starting from taxenes available in multigram amounts from widespread ornamental yews (10deacetylbaccatin Ill (4) and 2'-deacetoxyaustrospicatine ( )), two dimeric taxoids (3a, 3b) with potential dual target specificity ([3-tubulin end P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.

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