Synthesis and biological evaluation of gramicidin S dimers
✍ Scribed by Grotenbreg, Gijsbert M.; Witte, Martin D.; van Hooft, Peter A. V.; Spalburg, Emile; Rei�, Philipp; Noort, Daan; de Neeling, Albert J.; Koert, Ulrich; van der Marel, Gijsbert A.; Overkleeft, Herman S.; Overhand, Mark
- Book ID
- 119953835
- Publisher
- Royal Society of Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 218 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B414618B
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## Abstract Gramicidin S (GS) is a cyclo‐decapeptide antibiotic isolated from __Bacillus brevis__. The structural studies have shown that GS forms a two‐stranded antiparallel β‐sheet imposed by two II′ β‐turns. Despite its wide Gram+ and Gram− antimicrobial spectrum, GS is useless in therapy becaus
Bifunctional, heterodimeric compounds were synthesized to test their ability to create polyvalent arrays between DNA and microtubules in cells. Each dimer was examined for the capacity to bind to microtubules and for cytotoxicity against MES-SA and MES-SA/Dx5 cell lines.