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Synthesis and evaluation of C-seco paclitaxel analogues

✍ Scribed by Giovanni Appendino; Bruno Danieli; Jasmin Jakupovic; Emanuela Belloro; Giovanni Scambia; Ezio Bombardelli

No coin nor oath required. For personal study only.

✦ Synopsis

Starting from 7,9-diTes-10-dehydro C-secobaccatin Ili (4a), C-seco analogues of paclitaxel retaining biological activity were synthesised.

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