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Synthesis and conformational analysis of pyrimidine nucleoside analogues with a rigid sugar moiety

✍ Scribed by Magnus Björsne; Tomas Szabó; Bertil Samuelsson; Björn Classon

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
563 KB
Volume
3
Category
Article
ISSN
0968-0896

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✦ Synopsis

In order to obtain rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues were synthesized starting from cyclopentanone. The C-3' is fused to C-4' via a propylene linker in order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety should be restricted to mainly the C-1'-exo conformation.

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✍ Natasha Goulioukina; Johny Wehbe; Damien Marchand; Roger Busson; Eveline Lescrin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 German ⚖ 255 KB

## Abstract The synthesis of nicotinamide adenine dinucleotide (NAD) analogues in which the ribose unit of the nicotinamide moiety is replaced by a hexitol, altritol, and cyclohexenyl sugar mimic is described.