## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Synthesis of Spacered Nucleoside Analogues Comprising a Difluorocyclopropane Moiety.
✍ Scribed by Rene Csuk; Gisela thide
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 63 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Novel spaeered cyclopropane nucleoside analogues possessing both a hydroxyethyl group and an additional methylene spacer between the base and the ring were synthesized starting from 3-buten-l-ol. After tetrahydropyranylation, eyelopropanation, and reduction the target molecules were obtained by Mits
## Synthesis of Spacered Cyclopropyl Nucleoside Analogues as Potential Antiviral Agents -[i.e. compounds of type (I) and (II), required for structure-activity relationship studies]. -(CSUK, RENE; KERN, ANJA;
In order to obtain rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues were synthesized starting from cyclopentanone. The C-3' is fused to C-4' via a propylene linker in order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety should be restr
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