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Synthesis of spacered cyclopropyl nucleoside analogues as potential antiviral agents

✍ Scribed by René Csuk; Anja Kern

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 969 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00467-6

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✦ Synopsis

Novel spaeered cyclopropane nucleoside analogues possessing both a hydroxyethyl group and an additional methylene spacer between the base and the ring were synthesized starting from 3-buten-l-ol. After tetrahydropyranylation, eyelopropanation, and reduction the target molecules were obtained by Mitsunobu reactions followed by two consecutive deprotection steps.

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