✦ LIBER ✦

Synthesis and characterization of the potent cannabinoid agonist [naphthyl-3H] WIN 55212-2 at high specific activity

✍ Scribed by Richard J. Seguin; Crist N. Filer

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 79 KB
Volume: 46
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.644

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

[Naphthyl‐^3^H] WIN 55212‐2 was prepared at high specific activity by the catalytic tritiation of dibromo precursor 3. Product 4 was characterized by chromatography as well as tritium NMR and proven to be a useful radioligand. Copyright © 2002 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Synthesis and characterization of [vinyl

Synthesis and characterization of [vinylidene-3H] (−)-α-kainic acid at high specific activity

✍ David G. Ahern; Richard J. Seguin; Crist N. Filer 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 80 KB

## Abstract [Vinylidene‐^3^H] (−)‐α‐Kainic acid was prepared by means of a Wittig reaction with a protected ketone precursor and has proved useful as a tool to study neuroexcitatory amino acid receptors. Copyright © 2002 John Wiley & Sons, Ltd.

The preparation and characterization of

The preparation and characterization of [3H] histamine.2HCl at high specific activity1

✍ Crist N. Filer; David G. Ahern 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 292 KB

The preparation and characterization of

The preparation and characterization of (±)-[phenoxy-3H(N)] phenoxybenzamine hydrochloride at high specific activity

✍ Crist N. Filer; Robert Fazio; John Morrison; David G. Ahern 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 309 KB

The synthesis of glycine receptor radiol

The synthesis of glycine receptor radioligands [21, 22-3H] dihydrostrychnine and [2-3H] strychnine at high specific activity

✍ Crist N. Filer; David G. Ahern 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 351 KB

An expedient synthesis of high specific

An expedient synthesis of high specific activity tritium labelled 4-fluoro-1-[1-(2-thienyl)]cyclohexylpiperidine ([3H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex

✍ Neile A. Grayson; Brian R. de Costa; Joannes T. M. Linders; Kenner C. Rice 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 319 KB 👁 1 views

## Abstract [^18^F]4‐Fluoro‐1‐[1‐(2‐thienyl)cyclohexyl)]piperidine is a ligand potentially useful for positron emission tomography of the PCP/NMDA receptor complex in the mammalian brain. The tritium‐labelled title compound was synthesized in 5 steps starting with cyclohexanone. Catalytic tritiolys

The synthesis of three isotopomers of 2-

The synthesis of three isotopomers of 2-methyl-2-(4-[3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl]phenoxy)propionic acid, a potent and selective peroxisome proliferator-activated receptor alpha agonist

✍ Fengjiun Kuo; Dean K. Clodfelter; Nagy A. Farid; William J. Wheeler; Lennon H. M 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB

## Abstract Although fenofibrate (**1a**) is commercially available and clinically effective in lowering serum triglycerides, its activity and sub‐type selectivity at the PPARα receptors are only moderate; therefore, there exists a need for more potent and sub‐type selective PPARα agonists. To that