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Synthesis and characterization of new 3′-3′ linked oligodeoxyribonucleotides for alternate strand triple helix formation

✍ Scribed by Lorenzo De Napoli; Giovanni Di Fabio; Anna Messere; Daniela Montesarchio; Domenica Musumeci; Gennaro Piccialli

Book ID
104209524
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
903 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

Protected forms of 1,2,3-propanetriol and cis, cis-l,3,5-cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3'-3' linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3'-phosphoramidites as building blocks. UV thermal denaturation analysis showed the ability of ODNs with this inversion of polarity motif to cooperatively hybridize with duplexes of the type 5'-(Pu)m(PY)n-3' in an alternate strand recognition approach.

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