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Synthesis of 3′−3′-Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

✍ Scribed by Jussara Amato; Aldo Galeone; Giorgia Oliviero; Luciano Mayol; Gennaro Piccialli; Michela Varra

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 168 KB
Volume: 2004
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200300803

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✦ Synopsis

Abstract

Oligonucleotides with a 3′−3′ inversion of polarity, containing an acridine moiety attached to the nucleotide base flanking the 3′−3′ phosphodiester bond, have been synthesised, characterised and used to form alternate‐strand triple helix complexes. These have been investigated by UV melting studies and CD experiments. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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