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Synthesis and Characterization of Enantiomeric anti -2-Fluorobenzo[ a ]pyrene-7,8-dihydrodiol-9,10-epoxides and Their 2‘-Deoxyguanosine and Oligodeoxynucleotide Adducts

✍ Scribed by Yang, Tianle; Huang, Yanhe; Cho, Bongsup P.


Book ID
126781634
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
377 KB
Volume
19
Category
Article
ISSN
0893-228X

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Novel trifluoroethanol mediated synthesi
✍ Andagar R Ramesha; Heiko Kroth; Donald M Jerina 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 74 KB

The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively