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New and Highly Efficient Synthesis of Cis - and Trans -Opened Benzo[ a ]pyrene 7,8-Diol 9,10-Epoxide Adducts at the Exocyclic N 2 -Amino Group of Deoxyguanosine
β Scribed by Kroth, Heiko; Yagi, Haruhiko; Seidel, Albrecht; Jerina, Donald M.
- Book ID
- 126799256
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 121 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively