A Novel Synthetic Method for Cis-Opened Benzo[ a ]pyrene 7,8-Diol 9,10-Epoxide Adducts at the Exocyclic N 6 -Amino Group of Deoxyadenosine
β Scribed by Pilcher, Anthony S.; Yagi, Haruhiko; Jerina, Donald M.
- Book ID
- 127114290
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 62 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0002-7863
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The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively