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Mutational Consequences of Replication of M13mp7L2 Constructs Containing Cis-Opened Benzo[ a ]pyrene 7,8-Diol 9,10-Epoxide−Deoxyadenosine Adducts

✍ Scribed by Page, John E.; Pilcher, Anthony S.; Yagi, Haruhiko; Sayer, Jane M.; Jerina, Donald M.; Dipple, Anthony

Book ID
126919971
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
97 KB
Volume
12
Category
Article
ISSN
0893-228X

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ChemInform Abstract: New and Highly Effi
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Novel trifluoroethanol mediated synthesi
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✍ Andagar R Ramesha; Heiko Kroth; Donald M Jerina 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 74 KB

The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively