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Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A 1 Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene

✍ Scribed by Romagnoli, Romeo; Baraldi, Pier Giovanni; IJzerman, Adriaan P.; Massink, Arnault; Cruz-Lopez, Olga; Lopez-Cara, Luisa Carlota; Saponaro, Giulia; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Moorman, Allan R.; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia

Book ID
126296975
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
772 KB
Volume
57
Category
Article
ISSN
0022-2623

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Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A 1 Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene
✍ Romagnoli, Romeo; Baraldi, Pier Giovanni; IJzerman, Adriaan P.; Massink, Arnault 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 772 KB

A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or flexible) linker between the 5-position of the thiophene ring and a (h