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Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor

✍ Scribed by Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cruz-Lopez, Olga; Cara, Carlota Lopez; Saponaro, Giulia; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Baraldi, Stefania; Moorman, Allan R.; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia

Book ID
121525637
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
693 KB
Volume
22
Category
Article
ISSN
0968-0896

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Synthesis and Biological Evaluation of N
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A 1 Adenosine Receptor Based on 2-Amino-3-(4β€²-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene
✍ Romagnoli, Romeo; Baraldi, Pier Giovanni; IJzerman, Adriaan P.; Massink, Arnault πŸ“‚ Article πŸ“… 2014 πŸ› American Chemical Society 🌐 English βš– 772 KB

A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or flexible) linker between the 5-position of the thiophene ring and a (h