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Synthesis and Biological Effects of Novel 2-Amino-3-naphthoylthiophenes as Allosteric Enhancers of the A 1 Adenosine Receptor

✍ Scribed by Baraldi, Pier Giovanni; Romagnoli, Romeo; Pavani, Maria Giovanna; del Carmen Nuñez, Maria; Tabrizi, Mojgan Aghazadeh; Shryock, John C.; Leung, Edward; Moorman, Allan R.; Uluoglu, Canan; Iannotta, Valeria; Merighi, Stefania; Borea, Pier Andrea


Book ID
120200589
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
224 KB
Volume
46
Category
Article
ISSN
0022-2623

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A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or flexible) linker between the 5-position of the thiophene ring and a (h