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Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[ N -(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A 1 Adenosine Receptor

✍ Scribed by Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Cruz-Lopez, Olga; Iaconinoto, Maria Antonietta; Preti, Delia; Shryock, John C.; Moorman, Allan R.; Vincenzi, Fabrizio; Varani, Katia; Andrea Borea, Pier


Book ID
125529705
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
99 KB
Volume
51
Category
Article
ISSN
0022-2623

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Synthesis and Biological Evaluation of N
✍ Romagnoli, Romeo; Baraldi, Pier Giovanni; IJzerman, Adriaan P.; Massink, Arnault πŸ“‚ Article πŸ“… 2014 πŸ› American Chemical Society 🌐 English βš– 772 KB

A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or flexible) linker between the 5-position of the thiophene ring and a (h