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Synthesis and biological evaluation of new carbocyclic 2′,3′-didehydro-2′,3′-dideoxy and 3′-deoxy-2′-fluoropyrimidine and purinenucleosides

✍ Scribed by R. Guedj; E.E.E. Suhas; P.R.T. Frogier; R. Condom; S.R. Challand; A. Kirn; A.M. Aubertin


Book ID
113259316
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
56 KB
Volume
26
Category
Article
ISSN
0166-3542

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✍ Robert J. Young; Sue Shaw-Ponter; Jamie B. Thomson; J.Allen Miller; John G. Cumm 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 325 KB

The synthesis and antiviral evaluation of 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy 4'thionucleosides in both enantiomeric series are described. Enantiomeric 4-O-silylated-4hydroxymethyl-4-thiobutyrolactones, produced in high yield from chiral glycidols, provided suitable chiral synthons: phen