Asymmetric Synthesis and Antiviral Activities of l -Carbocyclic 2‘,3‘-Didehydro-2‘,3‘-dideoxy and 2‘,3‘-Dideoxy Nucleosides
✍ Scribed by Wang, Peiyuan; Gullen, Beth; Newton, M. Gary; Cheng, Yung-Chi; Schinazi, Reymond F.; Chu, Chung K.
- Book ID
- 127016898
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 142 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The synthesis and antiviral evaluation of 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy 4'thionucleosides in both enantiomeric series are described. Enantiomeric 4-O-silylated-4hydroxymethyl-4-thiobutyrolactones, produced in high yield from chiral glycidols, provided suitable chiral synthons: phen
We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.