Synthesis and Biological Evaluation of Cyclophostin: A 5′,6″-Tethered Analog of Adenophostin A
✍ Scribed by Martin de Kort; Anouk D. Regenbogen; Herman S. Overkleeft; R.A. John Challiss; Yoriko Iwata; Shuichi Miyamoto; Gijs A. van der Marel; Jacques H. van Boom
- Book ID
- 104202822
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 266 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Phosphonate analogs / Mannose 6-phosphate (M6P) / Receptors / Recognition markers / Phosphonates / Natural products Two β-hydroxyphosphonate analogs of M6P have been prepared by condensation of the lithiated anion of methyldiethylphosphonate with the C-6 carbonyl of a mannose derivative. The diaster
A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.
The recently isolated marine natural product pseudoceratidine (1) has been synthesized from 2-trichloroacetylpyrrole. Bromination in the 4-and 5-position followed by nucleophilic displacement of the trichloromethyl group with spermidine gave 1 in 79 g yield. The procedure is general and can easily b
Salvinorin A (1), the main active ingredient of Salvia divinorum, is a potent and selective κ opioid receptor (KOPR) agonist. Based on the SAR, its C-2 position is one of the key binding sites and has very little space tolerance (3-4 carbons atoms) and limited to only lipophilic groups. In our attem