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Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

✍ Scribed by Georg Jaeschke; Richard Porter; Bernd Büttelmann; Simona M. Ceccarelli; Wolfgang Guba; Bernd Kuhn; Sabine Kolczewski; Jörg Huwyler; Vincent Mutel; Jens-Uwe Peters; Theresa Ballard; Eric Prinssen; Eric Vieira; Jürgen Wichmann; Will Spooren


Book ID
108074245
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
206 KB
Volume
17
Category
Article
ISSN
0960-894X

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Synthesis of [3H]fenobam, a radioligand
✍ Thomas Hartung; Jens-Uwe Peters; Jürgen Wichmann; Christian Hubschwerlen; Georg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 102 KB

## Abstract Fenobam is a clinically efficacious anxiolytic that acts as metabotropic glutamate receptor 5 (mGlu5) antagonist by binding to an allosteric site. Other mGlu5 receptor antagonists such as MPEP and MTEP bind to the same allosteric site and are efficacious in preclinical models of anxiety