## Abstract Fenobam is a clinically efficacious anxiolytic that acts as metabotropic glutamate receptor 5 (mGlu5) antagonist by binding to an allosteric site. Other mGlu5 receptor antagonists such as MPEP and MTEP bind to the same allosteric site and are efficacious in preclinical models of anxiety
✦ LIBER ✦
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists
✍ Scribed by Georg Jaeschke; Richard Porter; Bernd Büttelmann; Simona M. Ceccarelli; Wolfgang Guba; Bernd Kuhn; Sabine Kolczewski; Jörg Huwyler; Vincent Mutel; Jens-Uwe Peters; Theresa Ballard; Eric Prinssen; Eric Vieira; Jürgen Wichmann; Will Spooren
- Book ID
- 108074245
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 206 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0960-894X
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## Abstract For Abstract see ChemInform Abstract in Full Text.