Synthesis and biological evaluation of C-3′NH/C-10 and C-2/C-10 modified paclitaxel analogues

Paclitaxel analogs modified in ring C: S

Paclitaxel analogs modified in ring C: Synthesis and biological evaluation

✍ Xian Liang; David G.I. Kingston; Byron H. Long; Craig A. Fairchild; Kathy A. Joh 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 1017 KB

Lead tetraeetate oxidation of 6u-hydmxy-7-epi-paclitaxel leads to C-.or-paclitaxel and C-seco-paclitaxel derivatives. Tetrapropylammonium perruthenate (TPAP) oxidation of a 6tx-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6ot-O-trifluoromethanesu

Synthesis and Biological Activity of C-6

Synthesis and Biological Activity of C-6 and C-7 Modified Paclitaxels

✍ Haiqing Yuan; Craig R Fairchild; Xian Liang; David G.I Kingston 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 160 KB

AbstractÐStructure modi®cation of paclitaxel at the C-6 and C-7 positions has been achieved using the readily available intermediate 6ahydroxy-7-epipaclitaxel (2). While a single diastereomer of the cyclic sul®te of 2 was prepared at lower temperature, both diastereomers were obtained at room temper

Synthesis and evaluation of C-seco pacli

Synthesis and evaluation of C-seco paclitaxel analogues

✍ Giovanni Appendino; Bruno Danieli; Jasmin Jakupovic; Emanuela Belloro; Giovanni 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 267 KB

Starting from 7,9-diTes-10-dehydro C-secobaccatin Ili (4a), C-seco analogues of paclitaxel retaining biological activity were synthesised.

Synthesis and biological evaluation of p

Synthesis and biological evaluation of paclitaxel analogs modified in ring C

✍ Xian Liang; David G.I. Kingston; Chii M. Lin; Ernest Hamel 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 240 KB

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Activity of C-6 and C-7 Modified Paclitaxels.

✍ Haiqing Yuan; Craig R. Fairchild; Xian Liang; David G. I. Kingston 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Evaluation of C-2 Modified Taxol Analogues (VI).

✍ Seok-Chan Kim; Man-Sik Moon; Kwan-Min Choi; Sook-Jin Jun; Hyon-Kyong Kim; Dai-Il 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 3 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v