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Synthesis and Biological Evaluation of a Fluorine-18 Derivative of Dasatinib

✍ Scribed by Veach, Darren R.; Namavari, Mohammad; Pillarsetty, Nagavarakishore; Santos, Elmer B.; Beresten-Kochetkov, Tatiana; Lambek, Caryl; Punzalan, Blesida J.; Antczak, Christophe; Smith-Jones, Peter M.; Djaballah, Hakim


Book ID
111859936
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
193 KB
Volume
50
Category
Article
ISSN
0022-2623

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Synthesis and biological evaluation of a
✍ Satish K. Chitneni; Tom De Ruymaeker; Jan Balzarini; Alfons M. Verbruggen; Guy M 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 125 KB

## Abstract The synthesis and preliminary biological evaluation of a lipophilic, fluorine‐18‐labeled 5‐ethynyl‐2′‐deoxyuridine derivative [^18^F]‐**3** is described. Initially, 5‐ethynyl‐2′‐deoxyuridine **5** was synthesized by coupling trimethylsilyl protected acetylene to 5‐iodo‐2′‐deoxyuridine *