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Fluorine-18 Click Radiosynthesis and Preclinical Evaluation of a New 18 F-Labeled Folic Acid Derivative

✍ Scribed by Ross, Tobias L.; Honer, Michael; Lam, Phoebe Y. H.; Mindt, Thomas L.; Groehn, Viola; Schibli, Roger; Schubiger, P. August; Ametamey, Simon M.

Book ID
120986349
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
590 KB
Volume
19
Category
Article
ISSN
1043-1802

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## Abstract Formation of islet amyloid deposits contributes to the progressive loss of beta‐cells in Type 2 diabetes. Islet amyloid is composed of islet amyloid polypeptide (IAPP). [(N‐Me)G^24^, (N‐Me)I^26^]hIAPP(22–27) peptide was found to bind human IAPP with high‐affinity and inhibit fibrillogen