𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting

✍ Scribed by Ribeiro Morais, G.; Gano, L.; Kniess, T.; Bergmann, R.; Abrunhosa, A.; Santos, I.; Paulo, A.

Book ID
121184413
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
564 KB
Volume
82
Category
Article
ISSN
0969-8043

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Radiosynthesis and in vivo evaluation of
Radiosynthesis and in vivo evaluation of a F-18-labeled pancreatic islet amyloid inhibitor
✍ Gopal Pathuri; Hrushikesh B. Agashe; Vibhudutta Awasthi; Hariprasad Gali 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 174 KB

## Abstract Formation of islet amyloid deposits contributes to the progressive loss of beta‐cells in Type 2 diabetes. Islet amyloid is composed of islet amyloid polypeptide (IAPP). [(N‐Me)G^24^, (N‐Me)I^26^]hIAPP(22–27) peptide was found to bind human IAPP with high‐affinity and inhibit fibrillogen

Novel probes for imaging amyloid-β: F-18
Novel probes for imaging amyloid-β: F-18 and C-11 labeling of 2-(4-aminostyryl)benzoxazole derivatives
✍ Hiroshi Shimadzu; Takahiro Suemoto; Masako Suzuki; Tsuyoshi Shiomitsu; Nobuyuki 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 149 KB

## Abstract 2‐(4‐Methylaminostyryl)‐6‐(2‐[^18^F]fluoroethoxy)benzoxazole ([^18^F]BF‐168) was prepared and found to be a potential probe for imaging amyloid‐__β__. The precursor, a 6‐(2‐tosyloxyethoxy)benzoxazole derivative, was fluorinated with [^18^F]KF and Kryptofix 222 in acetonitrile, and the c

A novel 18F-labeled pyridyl benzofuran d
A novel 18F-labeled pyridyl benzofuran derivative for imaging of β-amyloid plaques in Alzheimer’s brains
✍ Yan Cheng; Masahiro Ono; Hiroyuki Kimura; Shinya Kagawa; Ryuichi Nishii; Hideo S 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 456 KB

A potential probe for PET targeting b-amyloid plaques in Alzheimer's disease (AD) brain, FPYBF-1 (5-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylpyridin-2-amine), was synthesized and evaluated. In experiments in vitro, FPYBF-1 displayed high affinity for Ab(1-42) aggregates (K