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A novel 18F-labeled pyridyl benzofuran derivative for imaging of β-amyloid plaques in Alzheimer’s brains

✍ Scribed by Yan Cheng; Masahiro Ono; Hiroyuki Kimura; Shinya Kagawa; Ryuichi Nishii; Hideo Saji

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
456 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

A potential probe for PET targeting b-amyloid plaques in Alzheimer's disease (AD) brain, FPYBF-1 (5-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylpyridin-2-amine), was synthesized and evaluated. In experiments in vitro, FPYBF-1 displayed high affinity for Ab(1-42) aggregates (K i = 0.9 nM), and substantial labeling of b-amyloid plaques in sections of postmortem AD brains but not control brains. In experiments in vivo, [ 18 F]FPYBF-1 displayed good initial uptake (5.16%ID/g at 2 min postinjection) and rapid washout from the brain (2.44%ID/g at 60 min postinjection) in normal mice, and excellent binding to b-amyloid plaques in a murine model of AD. Furthermore, the specific labeling of plaques labeling was observed in autoradiographs of autopsied AD brain sections.

[ 18 F]FPYBF-1 may be a useful probe for imaging b-amyloid plaques in living brain tissue.

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