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18F-FESB: synthesis and automated radiofluorination of a novel 18F-labeled pet tracer for β-amyloid plaques

✍ Scribed by Piyush Kumar; Weizhong Zheng; Stephen A. McQuarrie; Jack H. Jhamandas; Leonard I. Wiebe

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
236 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

1-(2 0 -[ 18 F]-fluoroethoxy)-2,5-bis(4 0 -methoxystyryl)benzene ( 18 F-FESB) was synthesized in $76% radiochemical yield (specific activity >58.6 GBq or 1.58 Ci/mmol) in an Advanced Cyclotron Systems' automated synthesis unit by nucleophilic substitution of 1-(2 0 -toluenesulfonylethoxy)-2,5-bis(4 0 -methoxystyryl)benzene and purified using reversed phase column chromatography. When performed in the presence of ionic fluid, either 1-butyl-3-methylimidazolium tetrafluoroborate (Bmimtetrafluoroborate; BmimBF 4 ) or 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (Emimtriflate; EmimTFMS), radiochemical yields of 18 F-FESB ranged from 17 to 76%. The radiochemical yields were consistently lower ($3-7%) in the absence of these ionic fluids.

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