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A novel probe for imaging amyloid-β: Synthesis of F-18 labelled BF-108, an Acridine Orange analog

✍ Scribed by Hiroshi Shimadzu; Takahiro Suemoto; Masako Suzuki; Tsuyoshi Shiomitsu; Nobuyuki Okamura; Yukitsuka Kudo; Tohru Sawada

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
137 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 3‐(2‐[^18^F]fluoroethyl)ethylamino‐6‐diethylaminoacridine ([^18^F]BF‐108), a potential positron‐labelled probe for imaging amyloid‐β is described. The precursor tosylate derivative was fluorinated with [^18^F]KF/ Kryptofix 222 in acetonitrile, and the crude product was purified by semi‐preparative HPLC to give the radiolabelled BF‐108. The radiochemical purity was >95% and the maximum specific activity was 33.9 TBq/mmol at the end of the synthesis (EOS). The synthesis time was 130 min from the end of bombardment (EOB). Copyright © 2003 John Wiley & Sons, Ltd.

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