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Efficient synthesis of a fluorine-18 labeled biotin derivative

✍ Scribed by Michael Claesener; Hans-Jörg Breyholz; Sven Hermann; Andreas Faust; Stefan Wagner; Otmar Schober; Michael Schäfers; Klaus Kopka

Book ID
119334622
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
550 KB
Volume
39
Category
Article
ISSN
0969-8051

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## Abstract The synthesis and preliminary biological evaluation of a lipophilic, fluorine‐18‐labeled 5‐ethynyl‐2′‐deoxyuridine derivative [^18^F]‐**3** is described. Initially, 5‐ethynyl‐2′‐deoxyuridine **5** was synthesized by coupling trimethylsilyl protected acetylene to 5‐iodo‐2′‐deoxyuridine *