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Synthesis and biological evaluation of fluorinated acyclothionucleosides

✍ Scribed by Sonia Gouault-Bironneau; Aboubacary Sène; Jean-Marie Catel; Thierry Lequeux


Book ID
108170534
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
308 KB
Volume
129
Category
Article
ISSN
0022-1139

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A number of fluorine containing derivatives of daunomycin and Adriamycin have been synthesised with a fluorine substituent located on the C-9 side chain. They included the p-trifluoromethyl-(4) and p-fluorobenzoate (3) esters of Adriamycin and the trifluoro-ethyl-hydrazones of Adriamycin (2) and dau