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Synthesis and biological evaluation of a 13N-labeled opioid peptide

✍ Scribed by Saji, Hideo; Tsutsumi, Daisuke; Kiso, Yoshiaki; Iimuma, Satoshi; Mimoto, Tsutomu; Akaji, Kenichi; Magata, Yasuhiro; Nakamura, Hideo; Kita, Atsuko; Konishi, Junji; Yokoyama, Akira


Book ID
122005733
Publisher
Elsevier Science
Year
1992
Weight
526 KB
Volume
19
Category
Article
ISSN
0883-2897

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Synthesis and biological activity of hom
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## Abstract Two tris‐alkoxycarbonyl homoarginine derivatives, Boc‐Har{Ο‰,ω′‐[Z(2Br)]~2~}‐OH and Boc‐Har{Ο‰,ω′‐[Z(2Cl)]~2~}‐OH, were prepared by guanidinylation of Boc‐Lys‐OH, and used for the synthesis of neo‐endorphins and dynorphins. The results were compared with that obtained in the synthesis in