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Synthesis and Biological Evaluation of a Chitobiose-Based Peptide N -Glycanase Inhibitor Library

โœ Scribed by Witte, Martin D.; Horst, Danielle; Wiertz, Emmanuel J. H. J.; van der Marel, Gijsbert A.; Overkleeft, Herman S.


Book ID
121468356
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
441 KB
Volume
74
Category
Article
ISSN
0022-3263

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Phosphorylation of serine, threonine, and tyrosine controls fundamental mammalian cell events and is achieved by kinases which, in turn, are in dynamic relationship with phosphatases. Few selective inhibitors of protein tyrosine and dual specificity phosphatases are readily available. Based on SAR s