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Statistical Molecular Design, Parallel Synthesis, and Biological Evaluation of a Library of Thrombin Inhibitors

✍ Scribed by Linusson, Anna; Gottfries, Johan; Olsson, Thomas; Örnskov, Eivor; Folestad, Staffan; Nordén, Bo; Wold, Svante


Book ID
121296608
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
200 KB
Volume
44
Category
Article
ISSN
0022-2623

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Phosphorylation of serine, threonine, and tyrosine controls fundamental mammalian cell events and is achieved by kinases which, in turn, are in dynamic relationship with phosphatases. Few selective inhibitors of protein tyrosine and dual specificity phosphatases are readily available. Based on SAR s