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Design, synthesis and biological activity of a targeted library of potential tryptase inhibitors

✍ Scribed by Garc�a, M�nica; del R�o, Xavier; Silvestre, Sandra; Rubiralta, Mario; Lozoya, Estrella; Segarra, Victor; Fern�ndez, Dolors; Miralpeix, Montserrat; Aparici, M�nica; Diez, Anna


Book ID
121273565
Publisher
Royal Society of Chemistry
Year
2004
Tongue
English
Weight
414 KB
Volume
2
Category
Article
ISSN
1477-0520

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Phosphorylation of serine, threonine, and tyrosine controls fundamental mammalian cell events and is achieved by kinases which, in turn, are in dynamic relationship with phosphatases. Few selective inhibitors of protein tyrosine and dual specificity phosphatases are readily available. Based on SAR s