Synthesis and in vivo evaluation of N-13 labeled opioid peptide analogue for PET opiate receptor studies

Synthesis and preliminary in vivo evalua

Synthesis and preliminary in vivo evaluation of 4-[18F]fluoro-N-{2-[4-(6-trifluoromethylpyridin-2-yl)piperazin-1-yl]ethyl}benzamide, a potential PET radioligand for the 5-HT1A receptor

✍ M. Vandecapelle; F. Dumont; F. De Vos; K. Strijckmans; D. Leysen; K. Audenaert; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB 👁 1 views

## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)