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Synthesis and biological characteristics of the Technetium-99m triamide derivatives of mercaptoacetyltriglycine (MAG3)

✍ Scribed by S. M. Okarvi; P. Adriaens; A. M. Verbruggen

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 154 KB
Volume: 46
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.645

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✦ Synopsis

A number of MAG 3 -derivatives, containing the three-amide functions modified by inverting the sequence -CO-NH-to -NH-CO-in the firstand/or second-amide functions, have been labelled with 99m Tc in order to study the renal characteristics of the resulting MAG 3 -derivatives versus the reference 99m Tc-MAG 3 . The 99m Tc-MAG 3 -derivatives displayed HPLC-profiles similar to that of 99m Tc-MAG 3 . Furthermore, in mice they exhibited biological behaviour comparable or even superior to 99m Tc-MAG 3 , which indicates that the sequence of the first-and/or second-amide bond in 99m Tc-MAG 3 affects the biological behaviour only to a limited degree. However, in baboon the plasma clearance of the 99m Tc-MAG 3 -derivatives was relatively slower than 99m Tc-MAG 3 , which underlines the inter-species variability.

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